Design, synthesis and anti-HIV integrase evaluation of N-(5-chloro-8- hydroxy-2-styrylquinolin-7-yl)benzenesulfonamide derivatives

Abstract

Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8- hydroxyquinolin-7-yl]-benzenesulfonamide derivatives were designed and synthesized,and their possible HIV IN inhibitory activity was evaluated. © 2010 by the authors.