A preliminary study of intralesional, intralymph node, intravenous and intraperitoneal Corynebacterium parvum treatments in patients with advanced cancer

Abstract

Twenty‐one patients with squamous cell carcinoma of oral cavity and/or cervical lymph node and four patients with soft tissue sarcomas were given intralesional (2–4 mg/m2) and intralymph node (2–4 mg/m2) C. parvum injections followed by 5 intravenous (2–4 mg/m2) C. parvum treatments and conventional therapies. Seven patients with Stage III ovarian carcinomas were given intraperitoneal (2–4 mg/m2) C. parvum injections followed by conventional therapies. The local and systemic effects of the C. parvum treatments were described and the anti‐tumor effects were evaluated in this series of patients. Cancer 42:1912–1915, 1978. Copyright © 1978 American Cancer Society