Validation of collateral fractional flow reserve by myocardial perfusion imaging

Abstract

Background - Collateral fractional flow reserve (FFRcoll) is an index to quantify collateral blood flow, derived from coronary pressure measurements. Although well defined theoretically, its direct validation by myocardial perfusion imaging has not been established so far. Validating this index by myocardial perfusion imaging is the main aim of this study. Methods and Results - Twenty-four consecutive patients with stable angina and single left anterior descending artery stenosis underwent simultaneous measurement of aortic pressure (Pa), coronary wedge pressure (Pw), and central venous pressure (Pv) during balloon inflation. FFRcoll was calculated and compared with the extent and severity of the defect during coronary occlusion using 99mTc-sestamibi imaging at balloon inflation of the respective coronary artery. Although the pressure-derived collateral indexes (Pw, Pw/Pa, and FFRcoll) ranged widely, they were closely correlated with extent and severity scores of the nuclear occlusion images and superior to the ECG for that purpose. Of all parameters, FFRcoll correlated best with the severity score at imaging (r=-0.88), followed by the Pw/Pa ratio (r=-0.74) or Pw alone (r=-0.69). Conclusions -FFRcoll, calculated from coronary pressure during balloon occlusion, is highly correlated with the extent and severity of the defect at myocardial perfusion of the territory of the occluded artery and can be used for quantitative assessment of collateral blood flow in conscious humans.