Recognition of β-ketoalcohol-derived haptens by tailor-made antibodies

Abstract

Antibodies steamed from mice immunized towards three different conjugates do not recognize the β-ketoalcohol for which they have been elaborated. They however recognize the haptens, which bear the side chain linking them to the carrier proteins. We have synthesized and tested for recognition a series of compounds related to those haptens, especially stereoisomers and compounds bearing part of their structures. Results and hypotheses are presented below.