A Facile Synthesis of Cyanohydrin Trimethylsilyl Ethers by the Addition Reaction of Trimethylsilyl Cyanide with Aldehydes under Basic Condition

  • Kobayashi S
  • Tsuchiya Y
  • Mukaiyama T
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Abstract

In the presence of a catalytic amount of Lewis base such as amine, phosphine, arsine or antimony, trimethylsilyl cyanide (TMS-CN) smoothly reacts with aldehydes to afford the corresponding cyanohydrin trimethylsilyl ethers in excellent yields.

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Kobayashi, S., Tsuchiya, Y., & Mukaiyama, T. (1991). A Facile Synthesis of Cyanohydrin Trimethylsilyl Ethers by the Addition Reaction of Trimethylsilyl Cyanide with Aldehydes under Basic Condition. Chemistry Letters, 20(4), 537–540. https://doi.org/10.1246/cl.1991.537

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