Adjunctive fluvoxamine with clozapine

Abstract

Comments on the article by L. Williams et al (see record [rid]2002-04349-002[/rid]), which summarized treatment options for patients resistant to clozapine monotherapy. Lu and Lane suggest that, in the section on combining antidepressants with clozapine, several issues deserve more attention. For example, they disagree with the use of adjunctive antidepressants to reduce the cost of clozapine treatment. They also note that, although addition of fluvoxamine to low-dose clozapine was well-tolerated in a study conducted by Lu et al (2000), further studies are warranted to substantiate its safety and efficacy. (PsycINFO Database Record (c) 2018 APA, all rights reserved)