"Evaluation of Anti-Inflammatory, Analgesic and Antipyretic Properties of Neolamarckia Cadamba on Wistar Albino Rats"

Abstract

This Research Article focused on anti-inflammatory, analgesic and antipyretic activity of Neolamarckia cadamba leafs extract in order to evaluate the effect of ethanolic extract of Neolamarckia cadamba (Family: Rubiaceae) leafs showed significant anti-inflammatory, analgesic and antipyretic activity. The acute toxicity, orally evaluated in Rats, was found to be higher than 2000mg/kg. The antinociceptive response using tail flick and hot plate Method in rats were examined. The anti-inflammatory activity using carrageenan and antipyretic activity in yeast induced pyrexia in rats, were also examined. The extract at the dose 400mg/kg significantly reduced the numbers of pain but the extract significantly exerted protective effects on heat-induced pain in rat at all tested doses (lower dose 200mg/kg and high dose 400mg/kg p.o.). The percentage inhibition of oedema due to injection of carrageenan was found to be in accordance with the doses tested. The extract showed significant effect on yeast-induced fever in rats at higher dose of 400mg/kg and no promising results with 200 mg/kg lower dose level. It was observed that high dose of Neolamarckia cadamba extract showed greater decrease in analgesic, anti-inflammatory and antipyretic activity in comparison to the control group rats. Although these results provide a support for the traditional uses of Neolamarckia cadamba leafs, further studies are necessary to better evaluate its safety and modes of action