Phytochemical and biological study of Petrea volubilis L. (verbenaceae)

Abstract

Petrea volubilis L. was studied for its secondary metabolites and biological activities. The phytochemical screening of dried aerial parts revealed the presence of different constituents such as unsaturated sterols, triterpens, and flavonoids. The biological activities of the total extract and different fractions were evaluated in a series of bioassays (antioxidant, antiinflammatory, analgesic, antipyretic and antibacterial), the majority of them showed significant activities in the applied test systems. Extensive purification of the ethyl acetate extract led to isolation of apigenin (1), quercetin (2), 4', 6-dimethylscutellarien (3), hypogallic acid (3,4- dihydroxybenzoic acid) (4), trans-caffeic acid (5) vanillic acid (6) and acteoside (7). The structure elucidation of 1-7, was carried out by 1H-NMR, UV and MS analyses.