The influence of the isocyanoesters structure on the course of enzymatic Ugi reactions

Abstract

The impact of isocyanoesters structure on enzymatic three-component Ugi reactions course has been determined. The significant promiscuous ability of enzyme in Ugi-type reaction switching between four (U-4CR) and three (U-3CR) components reactions depending on the size of used isocyanoester. The application of short-chain cyanoesters up to isocyanpropionate leading to product of three component reaction exclusively while longer isocyanobutyrate gives only the product of four component reaction. The limitation of studied enzymatic Ugi reaction is a substrate selectivity of lipases.