Abstract
In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, 9) and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.
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CITATION STYLE
Oh, H., Kim, B. S., Bae, E. Y., Kim, M. S., Kim, B. Y., Lee, H. B., … Ahn, J. S. (2004). Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232. Journal of Antibiotics, 57(8), 528–531. https://doi.org/10.7164/antibiotics.57.528
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