Selective RNA versus DNA G-quadruplex targeting by situ click chemistry

Abstract

It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.