Potential compound of Curcuma xanthorrhiza and Curcuma zedoaria as Mortalin inhibitor to control cancer cell growth through computational study

Abstract

C. xanthorrhiza and C. zedoaria, anticancer agent widely used in Asia. Previous studies have identified that active compounds from both Curcuma are capable of inhibiting cancer cell growth and inducing apoptosis. However, the roles from its active compound for Mortalin inhibition in carcinogenesis process was unknown. The recent study shows that Mortalin also known as HSPA9/GRP75/mtHSP70 is a highly conserved heat-shock protein 70 family has various roles in carcinogenesis process in multiple ways and very complicated. This study analyzed the potential of active compound from both curcuma as Mortalin inhibitor to control cancer cell growth with the computational study. the results of binding affinity analysis through molecular docking show that some active compounds from both Curcuma have the potential as Mortalin inhibitor with smallest energy and same binding site with commercial Mortalin inhibitors. protein interaction analysis illustrates that Mortalin can interact with various protein including hspd1, timm17a, and hspa4. upregulation is it proteins expression have been identified as a diagnostic marker and poor prognosis factor for cancer. these data indicate that active compounds from both Curcuma have a promising opportunity as anticancer through Mortalin inhibitor mechanism. additional research is needed to validate the in vitro activity of the compounds.