Design and investigation of a dedicated PCF SPR biosensor for CANCER exposure employing external sensing

Abstract

In this investigation, a “photonic crystal fiber (PCF)”-based “surface plasmon resonance (SPR)” biosensor is proposed for the early detection of cancerous cells. The “finite element method (FEM)” is used for the numerical analysis from the proposed biosensor. The sensing capacity is investigated for the refractive index (RI), varying from 1.360 to 1.401 for various cancerous cells. The proposed biosensor has produced peak “wavelength sensitivity (WS)” of 12857.14nm/RIU and 14285.71nm/RIU for TMmode and TEmode, respectively. Maximum “amplitude sensitivity (AS)” of 13,240 RIU− 1 and 15010RIU-1 is obtained for TMmode and TEmode, respectively. Highest “sensor resolution (SR)” of 7.77×10-6RIU and 7.00×10-6RIU is obtained for TMmode and TEmode, respectively. The proposed sensor has produced a high “figure of merit (FOM)” of 17.39RIU-1 and 21.61RIU-1 corresponding to TMmode and TEmode, respectively. The linearity of resonance wavelength with RI for degree (2) produces a maximum value of the R-square as 0.9833 and 0.9870 for TMmode and TEmode, respectively. These maximum values of the sensing parameters are obtained for the breast cancer cell (MCF 7).