Frequent down regulation of the tumor suppressor gene A20 in multiple myeloma

10Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Multiple myeloma (MM) is a malignant clonal expansion of plasma cells in the bone marrow and belongs to the mature B-cell neoplams. The pathogenesis of MM is associated with constitutive NF-κB activation. However, genetic alterations causing constitutive NF-κB activation are still incompletely understood. Since A20 (TNFAIP3) is a suppressor of the NF-κB pathway and is frequently inactivated in various lymphoid malignancies, we investigated the genetic and epigenetic properties of A20 in MM. In total, of 46 patient specimens analyzed, 3 single base pair exchanges, 2 synonymous mutations and one missense mutation were detected by direct sequencing. Gene copy number analysis revealed a reduced A20 gene copy number in 8 of 45 (17.7%) patients. Furthermore, immunohistochemical staining confirmed that A20 expression correlates with the reduction of A20 gene copy number. These data suggest that A20 contributes to tumor formation in a significant fraction of myeloma patients.

Cite

CITATION STYLE

APA

Troppan, K., Hofer, S., Wenzl, K., Lassnig, M., Pursche, B., Steinbauer, E., … Neumeister, P. (2015). Frequent down regulation of the tumor suppressor gene A20 in multiple myeloma. PLoS ONE, 10(4). https://doi.org/10.1371/journal.pone.0123922

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free