Exogenous Testosterone Use and Central Serous Chorioretinopathy

Abstract

Purpose: To investigate the clinical characteristics of central serous chorioretinopathy (CSCR) in the setting of exogenous testosterone use. Methods: Retrospective chart review of patients with a history of exogenous testosterone use and a diagnosis of CSCR at a large retina practice. Patient charts were reviewed for vision, clinical examination, and optical coherence tomography (OCT) results at each visit. Results: Four hundred eighty patients with a diagnosis of CSCR were identified, of which 7 patients had a history of exogenous testosterone use (1.46%). Of all, 0 of 7 patients reported any other steroid use. Ages ranged from 36 to 55 (mean, 46.57), and all were male. Only the right eye was involved in all 7 patients. Testosterone was discontinued in only 1 of the 7 patients. Six of the 7 patients had a visual acuity of 20/40 or better at last follow-up (range, 20/20-4/200). Three (43%) of the 7 had resolution of subretinal fluid at their last visit. The most common formulation of testosterone was for intramuscular injection. Conclusions: Exogenous testosterone use was reported in 1.46% of patients with CSCR compared to 0.8% in the general male population. The majority of patients in this study recovered 20/40 or better vision and 43% had resolution of subretinal fluid on OCT, suggesting a generally favorable prognosis for CSCR in the setting of testosterone supplementation.