Hyperpolarized 13C MR for molecular imaging of prostate cancer

Abstract

Hyperpolarization using dissolution dynamic nuclear polarization has emerged as a versatile method to dramatically improve the MR signal of low-sensitivity nuclei. This technique facilitates the study of real-time metabolism in vitro and in vivo using 13Cenriched substrates and has been applied to numerous models of human disease. In particular, several mechanisms underlying prostate cancer have been interrogated using hyperpolarized 13C MR spectroscopy. This review highlights key metabolic shifts seen in prostate cancer, their study by hyperpolarized 13C MR spectroscopy, and the development of new platforms for metabolic study.