Serum PRL, TSH and Insulin Have Any Association with Insulin Resistance in Females with Polycystic Ovary Syndrome

Abstract

Background & Objective: One of the main public health issues in India that has medical repercussions is polycystic ovarian syndrome. As a result of its several etiological factors, including menstruation disruption, dyslipidemia, insulin resistance, obesity, and infertility. Hence, the main objective of the study is to evaluate the levels of serum PRL, TSH, FBG, Insulin and find out its association with HOMA-IR in females with PCOD. Method: - The cross-sectional study was conducted at SGT Medical College and Hospital, Gurgaon where a total of 200 females participated in the study, out of which 100 were considered as a study group and 100 were considered as a healthy control group between the age group of 18-45 years. Fasting blood samples were drawn to assess the levels of serum PRL, serum Insulin, TSH, FBS and were sent to laboratory. Result: A significant increase in the level of PRL, TSH, FBG, Insulin and HOMA-IR (p<0.001) were found in patients with PCOS in comparison with controls. Significant correlation was found between Serum Insulin and HOMA-IR. Further, no significant correlations were found between serum prolactin, TSH, FBG and HOMA-IR. Conclusion: Elevated levels of PRL, TSH and Insulin indicates the possibility of developing Insulin Resistance among patients of PCOS. Insulin Resistance may be helpful in diagnosing number of comorbidities that may lead to metabolic syndrome, hypertension, dyslipidaemia, glucose intolerance, and diabetes. Key words: Prolactin, Thyroid Stimulating Hormone, Fasting Blood Glucose, Homeostatic Model Assessment for Insulin Resistance, Polycystic Ovary Disorder