An effective, economic and green synthesis of carboxylic group substituted alkynes by Sonogashira coupling of halogenated aromatic acids with phenylacetylene has been developed. The coupling reaction proceeds well using Pd(OAc)(2)/TPPTS-CuI as catalyst with K(2)CO(3) as base in water. It is worth noting that this procedure avoids the protection/deprotection steps of carboxylic group and obtains the title compounds in good to excellent yields.
CITATION STYLE
Zhu, X.-Y., Wang, Y., Bai, F., Gao, G.-W., & Men, J. (2011). Protecting-group-free synthesis of carboxylic group substituted alkynes by Sonogashira coupling in neat water. Arkivoc, 2011(10), 99–106. https://doi.org/10.3998/ark.5550190.0012.a08
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