Abstract
Ustiloxin D, produced by the rice plant pathogen Ustilaginoidea virens, exhibits potent anti-tubulin activity. In order to elucidate the effects of functional groups in ustiloxin D on its activity, several derivatives were synthesized and their anti-tubulin activities were estimated. The N,N-dimethylamino derivative and the 14-O-methyl derivative were inactive (IC50 > 50 μM). 20-Hydroxymethylated ustiloxin D showed decreased inhibitory activity compared with ustiloxin D.
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CITATION STYLE
Morisaki, N., Mitsui, Y., Yamashita, Y., Koiso, Y., Shirai, R., Hashimoto, Y., & Iwasaki, S. (1998). Synthesis and anti-tubulin activity of ustiloxin D derivatives. Journal of Antibiotics, 51(4), 423–427. https://doi.org/10.7164/antibiotics.51.423
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