Anti-plasmodial sesquiterpenoids from the African Reneilmia cincinnata

Abstract

A new isodaucane sesquiterpenoid, 6,7,10-trihydoxyisodaucane, was isolated from the fruits of Reneilmia cincinnata, together with the known sesquiterpenoids oplodiol, oplopanone, 5E,10(14)-germacradien-1β,4β-diol, 1(10)E,5E-germacradien-4α-ol and eudesman-1,4,7-triol. A large amount of 5- hydroxy-3,7,4'-trimethoxyflavone was also isolated. Their structures were established by NMR techniques using 1D and 2D experiments. Three of the known sesquiterpenoids exhibited noteworthy anti-plasmodial activity against Plasmodium falciparum strains.