Treatment of Mild-to-Moderate Plaque Psoriasis with a New 650-Microsecond 1064-nm Nd:YAG Laser: Clinical and Dermoscopic Assessment

7Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.

Abstract

Introduction: About 70–80% of patients with psoriasis suffer from mild disease, and new modalities of topical treatment are urgently needed. This study aims to evaluate the effectiveness of 650-microsecond 1064-nm Nd:YAG laser in the therapy of psoriatic plaques and assess the utility of dermoscopy in predicting treatment response. Methods: Ten patients (mean age 37.4 ± 16.2 years) with stable plaque-type psoriasis were enrolled. The microsecond Nd:YAG laser treatment was applied to representative plaques on day 0, 7, 14, and 21. Clinical and dermoscopic photographs were performed at each session and follow-up visit (day 28). The disease severity was assessed using modified Psoriasis Area and Severity Index (mPASI) and Investigator Global Assessment (IGA). Patients were asked to rate the intensity of subjective symptoms, tolerability, and final outcome of the treatment. Results: Significant improvement of all mPASI components was observed, although the maximal mean reduction of total mPASI was only 30.3%. At baseline, three patients were assessed as “moderate” and seven as “mild” according to IGA, while on day 28, eight patients were scored as “mild” and two as “almost clear.” Complete resolution of itching was achieved in all patients. Local adverse reactions were also observed, which resulted in moderate tolerance of treatment in four patients. Three participants reported marked improvement on day 28, although 30% of patients observed no benefit. All subjects with dotted vessels, linear vessels, or hemorrhagic spots under dermoscopy at baseline reported some improvement after laser therapy. Three out of six patients with globular vessels were unresponsive to Nd:YAG laser. Conclusions: Microsecond Nd:YAG laser treatment may provide some improvement of psoriatic plaques, but its routine applicability seems to be limited due to ambiguous efficacy and local adverse reactions. Dermoscopy may be useful in identifying patients who will benefit from the procedure.

References Powered by Scopus

A systematic review of worldwide epidemiology of psoriasis

832Citations
N/AReaders
Get full text

Angiogenesis-a new target for future therapy

318Citations
N/AReaders
Get full text

308 nm UVB excimer laser for psoriasis

195Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Clinical value of dermoscopy in psoriasis

3Citations
N/AReaders
Get full text

Lasers for the treatment of psoriasis: a systematic review

3Citations
N/AReaders
Get full text

Clinical, dermoscopic, and ultrasonic monitoring of the response to biologic treatment in patients with moderate-to-severe plaque psoriasis

2Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Kołt-Kamińska, M., Żychowska, M., & Reich, A. (2021). Treatment of Mild-to-Moderate Plaque Psoriasis with a New 650-Microsecond 1064-nm Nd:YAG Laser: Clinical and Dermoscopic Assessment. Dermatology and Therapy, 11(2), 449–464. https://doi.org/10.1007/s13555-021-00486-z

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 2

67%

Professor / Associate Prof. 1

33%

Readers' Discipline

Tooltip

Medicine and Dentistry 1

33%

Pharmacology, Toxicology and Pharmaceut... 1

33%

Sports and Recreations 1

33%

Save time finding and organizing research with Mendeley

Sign up for free