Effect of oral premedication with gabapentin and trazodone combination on the MAC of isoflurane in dogs

Abstract

OBJECTIVE To determine the effect of the administration of oral gabapentin (20 mg/kg) and trazodone (8 mg/kg) on the MAC of isoflurane in dogs. METHODS 6 adult dogs (3 castrated males and 3 spayed females), aged 13.3 ± 1.5 months and weighing 36.8 ± 3.4 kg (mean ± SD), were each anesthetized twice, separated by at least 7 days. Dogs were randomly assigned to receive gabapen-tin (20 mg/kg orally) and trazodone (8 mg/kg orally) followed by maintenance isoflurane or maintenance isoflurane alone. For their second event, dogs received the other treatment. The MAC was determined using an iterative brack-eting technique with electric stimulation. Hemodynamic variables and vital parameters were assessed throughout the anesthetic episode. The effect of treatment on outcome variables was analyzed by use of a paired t test (P