Silica gel mediated oxidative C-O coupling of β-dicarbonyl compounds with malonyl peroxides in solvent-free conditions

Abstract

For the first time silica gel was observed to activate peroxides in oxidative coupling reactions. Here we report silica gel mediated oxidative C-O coupling of β-dicarbonyl compounds with cyclic diacyl peroxides affording α-acyloxy derivatives with 100% atom efficiency. The highest yields of coupling products were achieved in solvent free conditions. C-O coupling products were prepared in yields up to 86%.