New Constituents of the Aril of Myristica fragrans

Abstract

The following constituents were isolated for the first time from the aril of Myristica fragrans houtt.: 3-(3,4,5-trimethoxyphenyl)-2-(e)-propen-1-ol(1), 3-(3-methoxy-4,5-methylenedioxyphenyl)-2-(E)-propen-1-ol (2), 2,3-dihydro-7-methoxy-2-(3,4-dimethoxyphenyl)-3-methyl-5-(1-(E)-propenyl)benzofuran(3), fragransol-C(4), fragransol-D (5), 2,3-dimethyl-1,4-bis-(3,4-methylenedioxyphenyl)butan-1-ol (6), myristicanol-A(7) and myristicanol-B (8). Compounds 4, 5, 7 and 8 are new neolignans which may be formed by coupling of cinnamyl alcohol and propenylbenzene units. © 1988, The Pharmaceutical Society of Japan. All rights reserved.