Metabolism of Oxygen-15

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Abstract

OXYGEN-15 has been prepared by deuteron bombardment of nitrogen molecules in the Medical Research Council cyclotron at Hammersmith Hospital. Gases labelled with this isotope, which has a half-life of only 2 min., can be inhaled into the lungs and detected by external scintillation counters. The initial counting-rate in a given region of the lung is proportional to the regional ventilation1, and the rate of removal from the region during breath-holding is a measure of the regional blood-flow2. © 1960 Nature Publishing Group.

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Dollery, C. T., & West, J. B. (1960). Metabolism of Oxygen-15. Nature, 187(4743), 1121. https://doi.org/10.1038/1871121a0

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