Surface modifications of superparamagnetic iron oxide nanoparticles with polylactic acid-polyethylene glycol diblock copolymer and graphene oxide for a protein delivery vehicle

Abstract

As a protein delivery vehicle, superparamagnetic iron oxide nanoparticles (SPION) with an average size of 19.6 ± 4.8 nm were coated with polylactic acid (PLA) (5000)-polyethylene glycol (PEG) (10000) diblock copolymer and single layer graphene oxide (GO). Bovine serum albumin was selected as the model protein, and the drug loading capacity of the designed vehicle is 2013 ± 79 mg g-1. The drug release result shows that the average percentage of cumulative drug release after 47 days in vitro is 37.7% ± 1.4%.