Mechanochemical synthesis of novel 1-[(N-Arylthiocarbamoyl)amidino]pyrazoles and their application in thiocarbamoylguanylations

Abstract

Guanidines are important for a variety of reasons, including their use in medicinal and industrial applications. Mechanochemistry is being increasingly adopted as a green-chemistry technique for solvent-free organic synthesis. The synthesis of novel 1-[(N-Arylthiocarbamoyl)amidino]pyrazoles and their use as guanylating agents for the conversion of amines to N-Alkyl-and N,N-cycloalkyl-N'-(N-Arylthiocarbamoyl)guanidines by solvent-based and solvent-free mechanochemical methods are described. Formula parented.