EasyStrata: Evaluation and visualization of stratified genome-wide association meta-Analysis data

Abstract

The R package EasyStrata facilitates the evaluation and visualization of stratified genome-wide association meta-Analyses (GWAMAs) results. It provides (i) statistical methods to test and account for between-strata difference as a means to tackle gene-strata interaction effects and (ii) extended graphical features tailored for stratified GWAMA results. The software provides further features also suitable for general GWAMAs including functions to annotate, exclude or highlight specific loci in plots or to extract independent subsets of loci from genome-wide datasets. It is freely available and includes a userfriendly scripting interface that simplifies data handling and allows for combining statistical and graphical functions in a flexible fashion.