Recent Achievements in the Synthesis of Sulfoximine Derivatives

Abstract

The sulfoximine derivatives are widely known for their potent biological and medicinal activities. Recently, due to the transition-metal catalysis, great advancements have been achieved in the synthesis of sulfoximine derivatives. Utilizing free NH-sulfoximines as the starting materials, various the direct N-H functionalizations can be accomplished, such as alkynylation, alkenylation, alkylation, arylation, etc. In addition, the ortho arene C(sp2)-H activation can also be obtained through C-H activation reaction with the assistance of S=NH as intramolecular directing groups, thus giving varies (hetero)aromatic molecules. N-H and C-H functionalization reactions of sulfoximines were summarized, and the mechanisms of some novel model reactions are also briefly discussed.