Simulated P wave morphology in the presence of endo-epicardial activation delay

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Abstract

Aims Evidences of asynchrony between epicardial and endocardial activation in the atrial wall have been reported. We used a computer model of the atria and torso to investigate the consequences of such activation delay on P wave morphology, while controlling for P wave duration. Methods and results We created 390 models of the atria based on the same geometry. These models differed by atrial wall thickness (from 2 to 3mm), transmural coupling, and tissue conductivity in the endocardial and epicardial layers. Among them, 18 were in baseline, 186 had slower conduction in the epicardium layer and 186 in the endocardial layer. Conduction properties were adjusted in such a way that total activation time was the same in all models. P waves on a 16-lead system were simulated during sinus rhythm. Activation maps were similar in all cases. Endo-epicardial delay varied between -5.5 and 5.5ms vs. 0 ± 0.5ms in baseline. All P waves had the same duration but variability in their morphology was observed. With slower epicardial conduction, P wave amplitude was reduced by an average of 20% on leads V3-V5 and P wave area decreased by 50% on leads V1-V2 and by 40% on lead V3. Reversed, lower magnitude effects were observed with slower endocardial conduction. Conclusion An endo-epicardial delay of a few milliseconds is sufficient to significantly alter P wave morphology, even if the activation map remains the same.

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Irakoze, É., & Jacquemet, V. (2018). Simulated P wave morphology in the presence of endo-epicardial activation delay. Europace, 20, III16–III25. https://doi.org/10.1093/europace/euy229

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