Macrolide-resistant Shigella sonnei

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Abstract

Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2′-phosphotransferase that inactivates macrolides. Emergence of the mph(A) gene in S. sonnei may limit usefulness of azithromycin for treatment of shigellosis.

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Boumghar-Bourtchai, L., Mariani-Kurkdjian, P., Bingen, E., Filliol, I., Dhalluin, A., Ifrane, S. A., … Leclercq, R. (2008). Macrolide-resistant Shigella sonnei. Emerging Infectious Diseases, 14(8), 1297–1299. https://doi.org/10.3201/eid1408.080147

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