Proteomic-genomic adjustments and their confluence for elucidation of pathways and networks during liver fibrosis

Abstract

Proteomics is the study of the functional aspect of all expressed proteins. Laudable progress has been made in context to protein profiles and interactions and this progress has been augmented with the help of the blueprint provided by the genomics field. Liver fibrosis is the starting point of various chronic liver diseases ultimately leading to cirrhosis. Current advances in high-throughput proteomic technologies have manifested the potential to reveal biomarkers for the diagnosis of liver fibrosis. This review explores the key up-to-date breakthroughs in proteo-genomics and their implementation to the important clinical question of liver fibrosis. The combination of proteomics with the informatics field, discovery of biomarkers, delineation of clinical pathways, challenges in proteomics for future research in relevance to clinical hepatology have been critically discussed.