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Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood-brain barrier be a disease “sanctuary” during venetoclax treatment?

Clinical Case Reports (2021) 9(4) 2249-2253
DOI: 10.1002/ccr3.4002
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Abstract

Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood-brain barrier and at what extend, especially in reduced doses given for drug-drug interactions.

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Dimou, M., Bitsani, A., Roumelioti, M., Dimitrakopoulou, A., Iliakis, T., Pardalis, V., … Panayiotidis, P. (2021). Richter’s transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood-brain barrier be a disease “sanctuary” during venetoclax treatment? Clinical Case Reports, 9(4), 2249–2253. https://doi.org/10.1002/ccr3.4002

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