Nematicidal alkaloids and related compounds produced by the fungus penicillium cf. Simplicissimum

Abstract

A new nematicidal alkaloid, peniprequinolone (1), together with the known alkaloids penigequinolones A and B (2a, 2b), 3-methoxy-4-hydroxy-4-(4′-methoxyphenyl)quinolinone (3), and 3-methoxy-4,6-dihydroxy-4-(4′-methoxyphenyl)quinolinone (4), were isolated from Penicillium cf. simplicissimum (Oudemans) Thom. Cyclopenin (5) and a compound (6a/6b) structurally related to cyclopenin also were isolated from the fungus, and their structures were established by spectroscopic analysis. The biological activities of 1, 2, 3, 4, and 5 were examined by a bioassay with root-lesion nematodes. © 2000, Taylor & Francis Group, LLC. All rights reserved.