A chemically defined medium for production of actinomycin D by Streptomyces parvulus

Abstract

A chemically defined medium consisting of D(+)fructose, L(-)threonine, K2HPO4, MgSO4·7H2O, ZnSO4·7H2O, CaCl2·2H2O, FeSO4·7H2O and deionized water, was developed to maximize the synthesis of actinomycin D by the Streptomyces parvulus DAUFPE 3124 strain. This medium resulted in the maximum antibiotic concentration of 133mg/L while using the original medium the production of actinomycin D was poor not surpassing 43mg/L.