Manejo de los trastornos hipertensivos del embarazo

Abstract

Pre-eclampsia is one of the main causes of maternal mortality worldwide. The timely and accurate diagnosis of this disease is, in many cases, a challenge for the clinician, due to the fact that the diagnosis is mainly based on non-specific clinical criteria and laboratory results. In many cases the clinical manifestations do not correlate appropriately with the severity of the disease. Recently, the use of angiogenesis related factors and their relationship with placental dysfunction and the consequent development of hypertensive disorders has been studied. The soluble FMS-like tyrosine kinase-1 (sFLt-1) and placental growth factor (PlGF) currently have a leading role in the management, diagnosis, and prognosis of hypertensive disorders during pregnancy. The current publication presents a clinical algorithm to aid the management of pregnant women with the clinical suspicion of PE using the sFLt-1/PlGF ratio.