Carbapenem-resistant Morganella morganii carrying bla KPC-2 or bla NDM-1 in the clinic: one-decade genomic epidemiology analysis

Abstract

Currently, infections attributable to carbapenem-resistant Morganella morganii (CRMM) isolates harboring bla KPC or bla NDM are on the rise, highlighting the increasing severity of acquired antimicrobial resistance. However, systematic phylogeographic and genetic characterization of these isolates worldwide is still lacking. In this study, we elucidated the spatial–temporal distribution and evolutionary trajectory of bla KPC and bla NDM genes within their core genetic environments. We emphasize the necessity of strengthening surveillance and controlling these organisms in clinical settings to prevent the generation of so-called "superbug" isolates.