Natural history of atopic dermatitis - Outside-inside-outside story

Abstract

In this review, I summarized recent studies about nonatopic dermatitis, IgE associated atopic dermatitis and autoallergic atopic dermatitis in the natural history of atopic dermatitis with gene-gene and gene-environment interaction. Also, new hypothesis of the mechanism of atopic dermatitis which was called OUTSIDE-INSIDE-OUTSIDE story wes introduced.