Recent Advances in the Construction of Bridged Rings through Cycloadditions and Cascade Reactions

Abstract

Bridged rings are frequently encountered in natural products and biologically active molecules, which have significant application in the field of medicinal chemistry, natural product chemistry, synthetic chemistry, material chemistry and life science. In recent years, with the unremitting efforts of a large number of chemists, a series of new methods have been developed for the efficient synthesis of bridged compounds. The detailed synthetic methods to access bridged compounds in the past five years involving cycloadditions and cascade reactions are summarized, and the advantages and problems of the current methods are briefly analyzed, which would provide useful reference for the researchers engaged in organic synthesis and related fields.