Abstract
A series of chalcones (1-9) and pyrazoles (10-18) was prepared to investigate their potential activity as Angiotensin I-Converting Enzyme (ACE) inhibitors. Their structures were verified by elemental analysis, UV, IR, MS, 1H NMR, 13C NMR, and 2D NMR experiments. Among tested compounds, chalcone 7 exerted the highest activity with an IC50 value of 0.219 mM, while the most potent pyrazole was 15 (IC50 value of 0.213 mM). © 2010 Elsevier Ltd. All rights reserved.
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Bonesi, M., Loizzo, M. R., Statti, G. A., Michel, S., Tillequin, F., & Menichini, F. (2010). The synthesis and Angiotensin Converting Enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives. Bioorganic and Medicinal Chemistry Letters, 20(6), 1990–1993. https://doi.org/10.1016/j.bmcl.2010.01.113
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