Abstract
The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica , has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumor cell lines showed antiproliferative activities (GI50) in the range 12-17 μM.
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APA
Urosa, A., Marcos, I. S., Díez, D., Lithgow, A., Plata, G. B., Padrón, J. M., & Basabe, P. (2015). Synthesis and bioactivity of Luffarin I. Marine Drugs, 13(4), 2407–2423. https://doi.org/10.3390/md13042407
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