Insights into protein allostery in the csor/rcnr family of transcriptional repressors

Abstract

CsoR/RcnR transcriptional repressors adopt a disc-shaped, all ?-helical dimer of dimers tetrameric architecture, with a fourhelix bundle the key structural feature of the dimer. Individual members of this large family of repressors coordinate Cu(I) or Ni(II)/Co(II) or perform cysteine sulfur chemistry in mitigating the effects of metal or metabolite toxicity, respectively. Here we highlight recent insights into the functional diversity of this fascinating family of repressors. © 2014 The Chemical Society of Japan.