Chemical profile of schinus molle L. Essential oil and its antihemostatic properties

Abstract

About 17.7 million people die each year from cardiovascular disorders and the essential oils have great importance in the development of research. The aim was to evaluate the chemical composition of the essential oil from Schinus molle (EOSM) and its antihemostatic activity. EOSM was obtained from leaves by hydrodistillation and characterized by GC-FID-MS. Anticoagulant assay was performed by activated Partial Thromboplastin Time (aPTT) and Prothrombin Time (PT) assays, and the platelet aggregation assays were performed using adenosine diphosphate (ADP) and collagen as inducers. Forty-one compounds were identified mainly sesquiterpenes (88.1%) of which epi-α-cadinol (22.8%) and γ-cadinene (9.7%) are the major compounds. EOSM did not show anticoagulant activity (40-400 mg/mL). EOSM oil was active against ADP inducer at 5 mg/mL (80%) and 40 mg/mL (48%), but against collagen the EOSM showed no activity. This is the first report on the antiplatelet action of Schinus molle.