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Phage capsid recognition triggers activation of a bacterial toxin-antitoxin defense system

Molecular Cell
DOI: 10.1016/j.molcel.2022.12.020
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Abstract

Zhang et al.1 reveal a previously unknown route to toxin activation whereby bacteriophage capsid proteins bind the antitoxin domain of the CapRel fused toxin-antitoxin system, triggering translational inhibition via pyrophosporylation of tRNAs and culminating in abortive infection-mediated phage resistance.

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APA

Smith, L. M., & Fineran, P. C. (2023, January 19). Phage capsid recognition triggers activation of a bacterial toxin-antitoxin defense system. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2022.12.020

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