Disruption of heat shock protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) interaction by (-)-Maackiain suppresses histamine h1 receptor gene transcription in Hela cells

Abstract

Background: The molecular mechanism of anti-allergic (-)-maackiain remains unknown. Results: (-)-Maackiain and Hsp90 inhibitors inhibited PKCδ activation and suppressed H1R gene expression. Conclusion: (-)-Maackiain is a novel Hsp90 pathway inhibitor, and its anti-allergic activity underlies the disruption of Hsp90- PKCδinteraction. Significance: Hsp90 is involved in H1R gene up-regulation, and its inhibition could be a novel therapeutic strategy for allergic rhinitis.