Controlled release of vitamin E from thermo-responsive polymeric physico-gel

Abstract

Thermo-sensitive copolymer consists of poly(2-ethoxyethyl vinyl ether) and poly(hydroxyethyl vinyl ether) (EOVE200-HOVE400), whose sol-gel transition temperature was 20.5°C, was synthesized and its applicability to a drug delivery system was examined. Vitamin E (VE) was enclosed in EOVE200-HOVE400 and the release of VE was measured by varying the temperature 10⇔30°C. There was no release of VE from EOVE200-HOVE400 at 30°C, while VE was released when the temperature was reduced to 10°C. © 2003 Pharmaceutical Society of Japan.