Cytochrome P450 Cyp26a1 alters spinal motor neuron subtype identity in differentiating embryonic stem cells

Abstract

Background:How to differentiate embryonic stem cells into specific neuronal types is a key question. Results:Lack of Cyp26a1 results in increased ALDH1a2 and Hoxc6, markers of lateral motor column identity. Conclusion:The cytochrome P450 enzyme Cyp26a1 plays a critical role in specifying motor neuron columnar subtypes. Significance:Blocking Cyp26a1 has therapeutic potential in regenerative medicine, neurodegenerative diseases, and cancer therapies. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.