Comparison of Dorzolamide-Timolol Fixed Combination and Latanoprost, Effects on Intraocular Pressure and Ocular Pulse Amplitude

Abstract

PURPOSE: To compare dorzolamide‐timolol fixed combination (DTFC) and latanoprost with regard to their effects on intraocular pressure (IOP) and ocular pulse amplitude (OPA). METHODS: Sixty eyes of 60 patients with open angle glaucoma or glaucoma suspect were included in the present study. Patients were divided into 2 groups, DTFC‐treated (n = 30) and latanoprost‐treated (n = 30). IOP and OPA were measured with dynamic contour tonometer (DCT) and Goldmann applanation tonometer (GAT), before and at least 1 month after treatment. RESULTS: GAT IOP, DCT IOP and OPA decreased by 2.25 +/‐ 2.23 mm Hg, 1.97 +/‐ 2.06 mm Hg, and 0.14 +/‐ 0.88 mm Hg, respectively in the DTFC‐treated group. In the latanoprost‐treated group, GAT IOP, DCT IOP and OPA was reduced by 2.74 +/‐ 2.96 mm Hg, 2.06 +/‐ 3.50 mm Hg, and 0.69 +/‐ 1.07 mm Hg, respectively. There was no significant difference (p = 0.311) in the decline of IOP between the 2 groups, but OPA of the DTFC‐treated group decreased less than the latanoprost‐treated group (p = 0.032). CONCLUSIONS: No significant differences were observed in the short‐term decline of IOP between the 2 medications. However, the influence of DTFC on OPA appeared negligible in the latanoprost‐treated group.