Antibiotic biosynthesis and secondary metabolism in high-yielding strains of Streptomyces, Penicillium chrysogenum and Acremonium chrysogenum

Abstract

In this article, the secondary metabolism as a basis for antibiotics production by industrial strains of Streptomyces, Penicillium chrysogenum and Acremonium chrysogenum is discussed. Images from transmission electron microscopy reveal some important features of the mycelial cells which are related to antibiotics biosynthesis. This discovery is important for further industrial strain improvement and has economic significance. Possibilities of new strategies for antimicrobial treatment are discussed.