Smoothing l1-penalized estimators for high-dimensional time-course data

Abstract

When a series of (related) linear models has to be estimated it is often appropriate to combine the different data-sets to construct more efficient estimators. We use l1-penalized estimators like the Lasso or the Adaptive Lasso which can simultaneously do parameter estimation and model selection. We show that for a time-course of high-dimensional lin- ear models the convergence rates of the Lasso and of the Adaptive Lasso can be improved by combining the different time-points in a suitable way. Moreover, the Adaptive Lasso still enjoys oracle properties and consistent variable selection. The finite sample properties of the proposed methods are illustrated on simulated data and on a real problem of motif finding in DNA sequences. © 2007, Ashdin Publishing. All rights reserved.